Thymoma and autoimmunity

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

Chronic mucocutaneous candidiasis (CMC) is frequently associated with T cell immunodeficiencies. Specifically, the proinflammatory IL-17A-producing Th17 subset is implicated in protection against fungi at epithelial surfaces. In autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED, or autoimmune polyendocrine syndrome 1), CMC is often the first sign, but the underlying immunod...

Thymoma.

A review of the evaluation, treatment, and end results for 52 patients with thymoma treated at The University of Texas M.D. Anderson Cancer Center (1950-1984) is presented. The objective of the study was to examine the influence of a number of clinical characteristics on survival, including histologic and staging classifications, associated diseases, symptom status, and treatment. Forty-nine pa...

Thymoma

Thymomas, with their diverse signs, symptoms and relationships to other systemic diseases, are not infrequently encountered. Histologic classification is now standardized. Thymoma is associated with other disorders, such as myasthenia gravis and pure red cell aplasia. Proper staging, careful histologic evaluation and appropriately selected therapy are necessary to ensure long-term survival.

Myotonic dystrophy and thymoma.

CTLA4 Gene Variants in Autoimmunity and Cancer: a Comparative Review

Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as Grave’s disease, on which a large body of multicentre data is accumulated. For years t...